I'm working on this same issue, I'll let you know what I dig up.
robert
I got it to the point of getting debug info..like so many others before me. I know it's possible -I'm not savvy enough with Linux, however, nor do I have the time to become so - dual booting sucks imo, so I'm back to winblows =\
there's this neat app @ sysinternals.com which tells you what registry keys are being accessed by a particular program (on win, of course)..if you have access to windows and install zbrush there, you might be able to copy all the keys zbrush accesses into ~.wine/drive_c/*.reg and run Z...naturally there are a ton of them being accessed. On top of that, there has to be a better way. hope you guys and gals have better luck than I.
robert