Nevermind. Figured it out.
First create a resize node in the tree directly after the file in node and call it conditional. This just reads the size in our expression so there is nothing more to do with that. Then, our tree branches off in 2 directions. The first one has no adjustments, the second branch has our adjustments. Bring them together with a mix node and in the percent value, past in the expression "conditional.xSize==640?100:0".
What this does is if the file size is 640, set the mix percent to 100 which uses one side of the branch, else set the mix percent to 0 and use the other side of the branch.